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DYANAVEL® XR (amphetamine): After an initial rapid rise in blood levels, a gradual tapering off throughout the day with no additional peaks

Pharmacokinetics (PK) describes the way in which a person’s body absorbs, distributes, metabolizes, and excretes a medication. The PK properties of DYANAVEL XR were studied in healthy adults who were given 7.5 mL (equivalent to 18.8 mg amphetamine base) of DYANAVEL XR compared to 30 mg (equivalent to 18.8 mg amphetamine base) of extended-release (ER) mixed amphetamine salt tablet. Blood samples were collected before and then at several time points after taking the drug. The amount of amphetamine in each sample was then measured in a laboratory.

As shown in the chart below, blood levels of amphetamine increased rapidly after taking DYANAVEL XR, reaching a peak around 4 hours. Levels then gradually decreased from 4 hours through 24 hours.

Blood levels of amphetamine in people who took DYANAVEL XR were compared to those in people who took ER mixed amphetamine salt tablet.

Mean d-amphetamine and l-amphetamine plasma concentration-time profiles

Mean d-amphetamine and l-amphetamine plasma concentration time profiles graph
Mean d-amphetamine and l-amphetamine plasma concentration time profiles graph

    LiquiXR ® technology is an ion exchange polymer chemistry that enables continuous release of the medication throughout the day.

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    MAS, mixed amphetamine salt.

    Important Safety Information & Approved Use

    DYANAVEL XR, Quillivant XR, and QuilliChew ER are federally controlled substances (CII) because they can be abused or lead to dependence. Keep these medicines in a safe place to prevent misuse and abuse. Selling or giving away these medicines may harm others and is against the law. Tell your doctor if you, your child, or any family members have ever abused or been dependent on alcohol, prescription medicines, or street drugs.

    See Additional Important Safety Information.