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Quillivant XR® (methylphenidate hydrochloride): Personalized dosing in a long-acting liquid with a low starting dose

Quillivant XR® (methylphenidate HCl) should be taken by mouth once daily in the morning.

  • Your healthcare provider will identify your child's dose by adjusting it up or down in small amounts based on your child's response to treatment
  • Quillivant XR comes with an oral dosing dispenser to help you measure the correct amount of medication
  • Quillivant XR can be taken with or without food
  • Take Quillivant XR exactly as prescribed, and remember that you MUST shake the bottle vigorously for at least 10 seconds prior to each use
Find out answers to FAQs about Quillivant XR dosing
Did you know...?
Quillivant XR was shown to begin working as quickly as 45 minutes after taking it.

How to take Quillivant XR® (methylphenidate HCI)

Read the Instructions for Use for Quillivant XR you received from your pharmacist before taking Quillivant XR and every time you get a refill so that you have the most up-to-date instructions.

If you have any questions, talk to your healthcare provider about your or your child’s medical condition or treatment.

Step 1

  • Remove the QUILLIVANT XR bottle and oral dosing dispenser from the box (See Figure A). If the oral dosing dispenser is missing or not provided, please contact your pharmacist for a replacement.

Figure A

Figure A Step 1 instructions

Step 2

  • Check and make sure that the QUILLIVANT XR bottle contains liquid medicine (See Figure B). If QUILLIVANT XR is still in powder form, do not use it. Return it to your pharmacist.

Figure B

Figure B Step 2 instructions

Step 3

  • Shake the bottle well (up and down) for at least 10 seconds before each use (See Figure C).

Figure C

Figure C Step 3 instructions

Step 4

  • Uncap the bottle and check that the bottle adapter has been fully inserted into the bottle (See Figure D).

Figure D

Figure D Step 4 instructions

Step 4 (continued)

  • If bottle adapter (See Figure E) has not been inserted by the pharmacist into the bottle, insert adapter into the bottle as shown (See Figure E and Figure G).

Figure E    Figure F

Figure E and F Step 4 instructions continued
  • After the bottle adapter has been fully inserted into the bottle (See Figure G), it should not be removed. If the bottle adapter has not been inserted and is missing from the box, contact your pharmacist.
  • The bottle adapter must be fully inserted and should be even with the mouth of the bottle and must remain in place to allow the child resistant cap to work the right way.

Figure G

Figure G Step 4 instructions continued

Step 5

  • Check the QUILLIVANT XR dose in milliliters (mL) as prescribed by your health care provider. Locate this number on the oral dosing dispenser (See Figure H).

Figure H

Figure H Step 5 instructions

Step 6

  • Insert tip of the oral dosing dispenser into the upright bottle and push the plunger all the way down (See Figure I).

Figure I

Figure I Step 6 instructions

Step 7

  • With the oral dosing dispenser in place, turn the bottle upside down. Pull the plunger to the number of mL you need (the amount of liquid medicine in Step 5 – See Figure J).

Figure J

Figure J Step 7 instructions

Step 7 (continued)

  • Measure the number of mL of medicine from the white end of the plunger (See Figure K).

Figure K

Figure K Step 7 instructions continued

Step 8

  • Remove the oral dosing dispenser from the bottle adapter.

Step 9

  • Slowly squirt QUILLIVANT XR directly into your or your child’s mouth (See Figure L).

Figure L

Figure L Step 9 instructions

Step 10

  • Cap the bottle tightly. Store the bottle upright at 59°F to 86°F (15°C to 30°C) (See Figure M).

Figure M

Figure M Step 10 instructions

Step 11

  • Clean the oral dosing dispenser after each use by placing in the dishwasher, or by rinsing with tap water (See Figure N).

Figure N

Figure N Step 11 instructions

Keep Quillivant XR and all medicines out of the reach of children.

Important Safety Information & Approved Use

DYANAVEL XR, Quillivant XR, and QuilliChew ER are federally controlled substances (CII) because they can be abused or lead to dependence. Keep these medicines in a safe place to prevent misuse and abuse. Selling or giving away these medicines may harm others and is against the law. Tell your doctor if you, your child, or any family members have ever abused or been dependent on alcohol, prescription medicines, or street drugs.

See Additional Important Safety Information.